CIFRAN (Cipro/ Ciproxin)500mg 200 tablet

Ciprofloxacin Information

Pronunciation

sip roe FLOKS a sin

What is this drug used for?

• It is used to treat or prevent bacterial infections.

Frequently reported side effects of this drug

• Diarrhea

• Vomiting

• Nausea

Other side effects of this drug: Talk with your doctor right away if you have any of these signs of:

• Tendon inflammation or rupture like pain, bruising, or swelling in the back of the ankle, shoulder, hand, or other joints

• Depression like thoughts of suicide, anxiety, emotional instability, agitation, irritability, panic attacks, mood changes, behavioral changes, or confusion

• Liver problems like dark urine, fatigue, lack of appetite, nausea, abdominal pain, light-colored stools, vomiting, or yellow skin.

• Kidney problems like unable to pass urine, blood in the urine, change in amount of urine passed, or weight gain

• Nerve problems like sensitivity to heat or cold; decreased sense of touch; burning, numbness, or tingling; pain, or weakness in the arms, hands, legs, or feet

• Low blood sugar like dizziness, headache, fatigue, feeling weak, shaking, fast heartbeat, confusion, increased hunger, or sweating

• High blood sugar like confusion, fatigue, increased thirst, increased hunger, passing a lot of urine, flushing, fast breathing, or breath that smells like fruit

• Fast heartbeat

• Abnormal heartbeat

• Passing out

• Chest pain

• Thrush

• Severe loss of strength and energy

• Vision changes

• Sensing things that seem real but are not

• Seizures

• Severe headache

• Trouble sleeping

• Nightmares

• Dizziness

• Restlessness

• Shortness of breath

• Bruising

• Bleeding

• Tremors

• Abnormal gait

• Sunburn

• Chills

• Sore throat

• Vaginal pain, itching, and discharge

• Muscle pain

• Muscle weakness

• Difficulty focusing

• Trouble with memory

• Injection site irritation

• Severe or persistent pain in abdomen

• Severe or persistent chest pain

• Severe or persistent back pain

• Clostridioides (formerly Clostridium) difficile-associated diarrhea like abdominal pain or cramps, severe diarrhea or watery stools, or bloody stools

• Stevens-Johnson syndrome/toxic epidermal necrolysis like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in mouth, throat, nose, or eyes

• Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.

Medication Safety Issues
Sound-alike/look-alike issues:

Ciprofloxacin may be confused with cephalexin

Cipro may be confused with Ceftin

Storage and Stability
Injection:

Premixed infusion: Store between 5°C to 25°C (41°F to 77°F); avoid freezing. Protect from light.

Vial: Store between 5°C to 30°C (41°F to 86°F); avoid freezing. Protect from light. Diluted solutions of 0.5 to 2 mg/mL in D51/4NS, D51/2NS, D5W, D10W, LR, NS are stable for up to 14 days refrigerated or at room temperature.

Microcapsules for oral suspension: Prior to reconstitution, store below 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). Protect from freezing. Following reconstitution, store at 25°C (77°F) for 14 days; excursions permitted to 15°C to 30°C (59°F to 86°F) for up to 14 days. Protect from freezing.

Tablet:

Immediate release: Store between 20°C to 25°C (68°F to 77°F); excursions are permitted between 15°C and 30°C (59°F and 86°F).

Extended release: Store at 25°C (77°F); excursions are permitted between 15°C and 30°C (59°F and 86°F).

Adverse Reactions

Dermatologic: Skin rash

Gastrointestinal: Abdominal pain (more common in children), diarrhea, dyspepsia, nausea, vomiting

Genitourinary: Vulvovaginal candidiasis

Hepatic: Abnormal hepatic function tests, increased serum alanine aminotransferase, increased serum aspartate aminotransferase

Local: Injection site reactions (IV)

Nervous system: Dizziness, headache, insomnia, nervousness, neurological signs and symptoms (IV: children), restlessness, somnolence

Neuromuscular & skeletal: Musculoskeletal signs and symptoms (children)

Respiratory: Asthma (children)

Miscellaneous: Fever