CYTODROX (HYDROXYUREA)500MG – 100 tablet

Hydroxyurea Information

Pronunciation

hye droks ee yoor EE a

What is this drug used for?

• It is used to treat a type of leukemia.

• It is used to treat cancer of the head and neck.

• It is used to treat sickle cell anemia.

• It may be given to you for other reasons. Talk with the doctor.

Frequently reported side effects of this drug

• Hair loss

• Nausea

• Lack of appetite

• Constipation

• Diarrhea

• Weight gain

• Headache

• Mouth sores

Other side effects of this drug: Talk with your doctor right away if you have any of these signs of:

• Infection

• Mole changes

• Skin growths

• Severe pulmonary disorder like lung or breathing problems like difficulty breathing, shortness of breath, or a cough that is new or worse

• Bruising

• Bleeding

• Severe loss of strength and energy

• Skin ulcers

• Skin changes

• Nail changes

• Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.

Medication Safety Issues

Product Availability

Siklos 100 mg functionally scored tablets: FDA approved May 2019; anticipated availability is currently unknown. Consult the prescribing information for additional information.

Storage and Stability

Droxia, Hydrea: Store at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F). Keep bottle tightly closed.

Siklos: Store at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F). Keep bottle tightly closed; use split tablets within 3 months.

Adverse Reactions

Central nervous system: Headache, severe nervous system disease

Dermatologic: Dermal ulcer (Antonioli 2012), dermatological reaction, eczema (infants and children [Thornburg 2012]), leg ulcer (Hernández-Boluda 2011), skin depigmentation

Endocrine & metabolic: Vitamin D deficiency, weight gain

Gastrointestinal: Acute mucocutaneous toxicity (Hernández-Boluda 2011), constipation, gastric distress (infrequent [Antonioli 2012]), gastritis, nausea, oral mucosa ulcer (infrequent [Hernández-Boluda 2011])

Genitourinary: Urinary tract abnormality

Hematologic & oncologic: Anemia, bone marrow depression (recovery: within 2 weeks), hemorrhage, leukemia, leukopenia, macrocytosis (MCV >97 [Randi 2005]), neutropenia, thrombocytopenia

Infection: Bacterial infection, infection, parvovirus B19 seroconversion, viral infection

Neuromuscular & skeletal: Panniculitis (Antonioli 2012)

Renal: Renal disease

Respiratory: Asthma (infants and children [Thornburg 2012])

Miscellaneous: Fever