Flagyl,Metronidazole – 540 tablets – 400mg

Metronidazole Information

Pronunciation

(met roe NYE da zole)

What is this drug used for?

• It is used to treat infections.

• It is used to prevent infections during bowel surgery.

• It may be given to you for other reasons. Talk with the doctor.

Frequently reported side effects of this drug

• Nausea

• Vomiting

• Diarrhea

• Constipation

• Lack of appetite

• Abdominal cramps

• Abdominal pain

• Joint pain

• Decreased sex drive

• Injection site irritation

• Metallic taste

Other side effects of this drug: Talk with your doctor right away if you have any of these signs of:

• Infection

• Liver problems like dark urine, fatigue, lack of appetite, nausea, abdominal pain, light-colored stools, vomiting, or yellow skin

• Change in balance

• Dizziness

• Passing out

• Headache

• Trouble speaking

• Seizures

• Thrush

• Vaginal pain, itching, and discharge

• Vision changes

• Irritability

• Depression

• Confusion

• Loss of strength or energy

• Trouble sleeping

• Burning or numbness feeling

• Aseptic meningitis like headache, fever, chills, severe nausea or vomiting, stiff neck, rash, sensitivity to lights, fatigue, or confusion

• Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.

Medication Safety Issues
Sound-alike/look-alike issues:

MetroNIDAZOLE may be confused with mebendazole, meropenem, metFORMIN, methotrexate, metoclopramide, miconazole

Storage/Stability

Oral: Store at 15°C to 25°C (59°F to 77°F). Protect the tablets from light.

Injection: Store at 20°C to 25°C (68°F to 77°F). Protect from light. Avoid excessive heat. Do not refrigerate. Do not remove unit from overwrap until ready for use. Discard unused solution.

Adverse Reactions

>10%:

Central nervous system: Headache (18%)

Gastrointestinal: Nausea (10% to 12%)

Genitourinary: Vaginitis (15%)

1% to 10%:

Central nervous system: Metallic taste (9%), dizziness (4%)

Dermatologic: Genital pruritus (5%)

Gastrointestinal: Abdominal pain (4%), diarrhea (4%), xerostomia (2%)

Genitourinary: Dysmenorrhea (3%), urine abnormality (3%), urinary tract infection (2%)

Infection: Bacterial infection (7%), candidiasis (3%)

Respiratory: Flu-like symptoms (6%), upper respiratory tract infection (4%), pharyngitis (3%), sinusitis (3%)

Frequency not defined:

Cardiovascular: Chest pain, facial edema, flattened T-wave on ECG, flushing, palpitations, peripheral edema, syncope, tachycardia

Central nervous system: Aseptic meningitis, ataxia, brain disease, cerebral lesion (reversible), chills, confusion, convulsions, depression, disulfiram-like reaction (with alcohol), drowsiness, dysarthria, hypoesthesia, insomnia, irritability, malaise, numbness, paresthesia, peripheral neuropathy, psychosis, seizure, vertigo

Dermatologic: Erythematous rash, hyperhidrosis, pruritus, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria

Endocrine & metabolic: Decreased libido

Gastrointestinal: Abdominal cramps, abdominal distress, anorexia, constipation, decreased appetite, dysgeusia, glossitis, hairy tongue, pancreatitis (rare), proctitis, stomatitis, vomiting

Genitourinary: Cystitis, dark urine (rare), dyspareunia, dysuria, urinary incontinence, urine discoloration, vaginal dryness, vulvovaginal candidiasis

Hematologic & oncologic: Agranulocytosis, eosinophilia, leukopenia, neutropenia (reversible), thrombocytopenia (reversible, rare)

Hepatic: Increased liver enzymes, jaundice, severe hepatotoxicity (patients with Cockayne syndrome)

Hypersensitivity: Anaphylaxis, hypersensitivity

Immunologic: DRESS syndrome, serum sickness-like reaction (joint pains)

Local: Inflammation at injection site (IV), injection site reaction

Neuromuscular & skeletal: Arthralgia, muscle spasm, myalgia, weakness

Ophthalmic: Abnormal eye movements (saccadic), nystagmus, optic neuropathy

Renal: Polyuria

Respiratory: Dyspnea, nasal congestion, rhinitis

Miscellaneous: Fever