GRANICIP DT (KYTRIL) 1MG – 4 tablet

Granisetron Information

 

Pronunciation

gra NI se tron

 

What is this drug used for?

• It is used to prevent upset stomach and throwing up.

Frequently reported side effects of this drug

• Headache

• Fatigue

• Loss of strength and energy

• Diarrhea

• Trouble sleeping

• Heartburn

Other side effects of this drug: Talk with your doctor right away if you have any of these signs of:

• Severe dizziness

• Passing out

• Shortness of breath

• Chest pain

• Fast heartbeat

• Abnormal heartbeat

• Chills

• Sore throat

• Abdominal swelling

• Abdominal pain

• Severe skin irritation

• Severe injection site pain or irritation

• Injection site infection or persistent bleeding

• Persistent hard or tight skin at injection site

• Severe constipation

• Serotonin syndrome like dizziness, severe headache, agitation, sensing things that seem real but are not, fast heartbeat, abnormal heartbeat, flushing, tremors, sweating a lot, change in balance, severe nausea, or severe diarrhea

• Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.

 

Medication Safety Issues

Sound-alike/look-alike issues:

 

Product Availability

Granisol oral solution has been discontinued in the US for more than 1 year.

 

Storage and Stability

IV: Store at 15°C to 30°C (59°F to 86°F). Protect from light. Do not freeze vials. Stable when mixed in NS or D5W for at least 24 hours at room temperature.

Oral: Store tablet or oral solution at 15°C to 30°C (59°F to 86°F). Protect from light.

SubQ (extended-release injection): Store at 2°C to 8°C (36°F to 46°F); do not freeze. May be placed back in refrigerator after being kept at room temperature; may remain at room temperature for a maximum of 7 days. Protect from light.

Transdermal patch: Store at 20°C to 25°C (68°F to 77°F). Keep patch in original packaging until immediately prior to use.

 

Adverse Reactions

Cardiovascular: Hypertension (oral and IV), prolonged Q-T interval on ECG (>450 milliseconds, not associated with any arrhythmias)

Central nervous system: Agitation (IV), anxiety (oral and IV), central nervous system stimulation (IV), dizziness, drowsiness, headache (more common in oral and IV), insomnia (oral and IV)

Dermatologic: Alopecia, skin rash (IV)

Gastrointestinal: Abdominal pain, constipation (more common in oral and IV), decreased appetite, diarrhea (oral and IV), dysgeusia (IV), dyspepsia, nausea, vomiting

Hematologic & oncologic: Anemia, leukopenia, thrombocytopenia

Hepatic: Increased serum ALT (>2 x ULN), increased serum AST (>2 x ULN)

Neuromuscular & skeletal: Weakness (more common in oral)

Miscellaneous: Fever