Idrofos (Boniva)3mg

Percentages vary based on frequency of administration (daily vs monthly). Unless specified, percentages are reported with oral use.

>10%:

Gastrointestinal: Dyspepsia (4% to 12%)

Neuromuscular & skeletal: Back pain (4% to 14%)

Respiratory: Upper respiratory tract infection (2% to 34%)

1% to 10%:

Cardiovascular: Hypertension (6% to 7%)

Central nervous system: Headache (3% to 7%), dizziness (1% to 4%), fatigue (3%), insomnia (1% to 2%), depression (2%)

Dermatologic: Skin rash (1% to 2%)

Gastrointestinal: Abdominal pain (5% to 8%), diarrhea (2% to 7%), nausea (4% to 5%), dental disease (4%), constipation (3% to 4%), vomiting (3%), gastritis (2%), gastroenteritis (3%)

Genitourinary: Urinary tract infection (2% to 6%), cystitis (3%)

Hypersensitivity: Acute phase reaction-like symptoms (IV: 10%; oral: 3% to 9%), hypersensitivity reaction (3%)

Infection: Influenza (4% to 8%)

Local: Injection site reaction (<2%)

Neuromuscular & skeletal: Limb pain (1% to 8%), arthralgia (4% to 9%), myalgia (1% to 6%), arthropathy (4%), weakness (4%), localized osteoarthritis (1% to 3%), muscle cramps (2%)

Respiratory: Bronchitis (3% to 10%), pneumonia (6%), nasopharyngitis (3% to 4%), flu-like symptoms (1% to 3%), pharyngitis (3%)

Postmarketing and/or case reports: Acute renal failure, anaphylactic shock, anaphylaxis, angioedema, bronchospasm, bullous dermatitis, erythema multiforme, exacerbation of asthma, femur fracture (diaphyseal or subtrochanteric), hypocalcemia, iritis, musculoskeletal pain (bone, joint, or muscle; incapacitating), ophthalmic inflammation, osteonecrosis (oro-facial sites including the external auditory canal), osteonecrosis of the jaw, prolonged Q-T interval on ECG (Bonilla 2014), scleritis, Stevens-Johnson syndrome, uveitis