What is this drug used for?
• It is used for many health problems like allergy signs, asthma, adrenal gland problems, blood problems, skin rashes, or swelling problems. This is not a list of all health problems that this drug may be used for. Talk with the doctor.
Frequently reported side effects of this drug
• Nausea
• Vomiting
• Trouble sleeping
• Restlessness
Other side effects of this drug: Talk with your doctor right away if you have any of these signs of:
• Infection
• High blood sugar like confusion, fatigue, increased thirst, increased hunger, passing a lot of urine, flushing, fast breathing, or breath that smells like fruit
• Adrenal gland problems like severe nausea, vomiting, severe dizziness, passing out, muscle weakness, severe fatigue, mood changes, lack of appetite, or weight loss
• Low potassium like muscle pain or weakness, muscle cramps, or an abnormal heartbeat
• Pancreatitis like severe abdominal pain, severe back pain, severe nausea, or vomiting
• Cushing syndrome like weight gain in upper back or abdomen; moon face; severe headache; or slow healing
• Skin changes like acne, stretch marks, slow healing, or hair growth
• DVT like swelling, warmth, numbness, change in color, or pain in the extremities
• Severe loss of strength and energy
• Fast heartbeat
• Confusion
• Sweating a lot
• Dizziness
• Passing out
• Shortness of breath
• Excessive weight gain
• Swelling of arms or legs
• Severe headache
• Fast heartbeat
• Slow heartbeat
• Abnormal heartbeat
• Chest pain
• Menstrual changes
• Joint pain
• Bone pain
• Vision changes
• Mood changes
• Behavioral changes
• Trouble with memory
• Trouble focusing
• Sensing things that seem real but are not
• Seizures
• Burning or numbness feeling
• Bruising
• Bleeding
• Severe abdominal pain
• Black, tarry, or bloody stools
• Vomiting blood
• Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.
Pronunciation
(PRED ni sone)
Medication Safety Issues
Sound-alike/look-alike issues:
PredniSONE may be confused with methylPREDNISolone, Pramosone, prazosin, prednisoLONE, PriLOSEC, primidone, promethazine
Generic Availability: US
May be product dependent
Storage and Stability
Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). Protect from light and moisture.
Oral solution, concentrate: Discard opened bottle after 90 days.
Adverse Reactions
Cardiovascular: Cardiac failure (in susceptible patients), hypertension
Central nervous system: Emotional lability, headache, increased intracranial pressure (with papilledema), myasthenia, psychiatric disturbance (including euphoria, insomnia, mood swings, personality changes, severe depression), seizure, vertigo
Dermatologic: Diaphoresis, facial erythema, skin atrophy, urticaria
Endocrine & metabolic: Cushing’s syndrome, decreased serum potassium, diabetes mellitus, fluid retention, growth suppression (children), hypokalemic alkalosis, hypothyroidism (enhanced), menstrual disease, negative nitrogen balance (due to protein catabolism), sodium retention
Gastrointestinal: Abdominal distention, carbohydrate intolerance, pancreatitis, peptic ulcer (with possible perforation and hemorrhage), ulcerative esophagitis
Hematologic & oncologic: Bruise, Kaposi’s sarcoma, petechia
Hepatic: Increased serum alkaline phosphatase, increased serum ALT, increased serum AST
Hypersensitivity: Anaphylaxis, hypersensitivity reaction
Infection: Infection
Neuromuscular & skeletal: Amyotrophy, aseptic necrosis of bones (femoral and humeral heads), osteoporosis, pathological fracture (long bones), rupture of tendon (particularly Achilles tendon), steroid myopathy, vertebral compression fracture
Ophthalmic: Exophthalmos, glaucoma, increased intraocular pressure, subcapsular posterior cataract
Miscellaneous: Wound healing impairment
Rare but important or life-threatening: Venous thrombosis (Johannesdottir 2013)
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