Retin-A gel 0.025% contains tretinoin, an active metabolite of Vitamin A, used as a topical treatment for acne vulgaris, to prevent and clear up pimples, whitehead and blackheads.

Retin-A gel general information

What is Retin-A gel used for?

Retin-A gel 0.025% is a topical medication used to treat acne vulgaris, to prevent the formation and spread of pimples (papules), spots or whiteheads (pustules) and blackheads (comedones). Retin-A gel 0.025% is an oil-free gel, particularly useful for oily skin and works by combating the processes in the skin that cause clogged pores and lead to pimples, spots and blackheads associated with acne, helping to clear up these skin blemishes as well as preventing the outbreak of new acne.

How does Retin-A gel work?

Retin-A gel 0.025% contains tretinoin, which is an active metabolite of Vitamin A that binds to intracellular receptors and modifies the way skin cells behave. Comedones (blackheads) form in hair follicles that become blocked by excess keratinized (hardened) epithelial skin cells. Tretinoin in Retin-A gel 0.025% is a keratolytic medication that prevents formation of new pimples and blackheads by blocking the hardening processes of the outer skin layer (keratinisation and cornification) and increasing the shedding of old hardened skin cells, while at the same time promoting growth of new skin cells. The combined effect of these actions is to speed up skin cell turnover, clear up pimples and blackheads and reduce the spread of acne.

What does Retin-A gel contain?

Retin-A gel 0.025% contains the active ingredient tretinoin 0.025%, a topical keratolytic medication used to treat acne.

Treating acne with Retin-A gel

Retin-A gel 0.025% contains tretinoin which is an active metabolite of Vitamin A and a keratolytic medication that changes the way skin cells grow and behave. Acne forms when over stimulation of the sebaceous glands (oil producing glands in hair follicles), which often happens in response a surge of androgen hormones at puberty, causes pores to become clogged with dead skin, and leads to the formation of new pimples, whitehead and blackheads (comedones), which can become infected and inflamed. Tretinoin in Retin-A gel 0.025% prevents formation of new pimples and blackheads by blocking the hardening processes of the outer skin layer (keratinisation and cornification) and increasing the shedding of old hardened skin cells, while at the same time promoting growth of new skin cells. The combined effect of these actions is to unblock pores and prevent them becoming clogged and inflamed, which reduces the outbreak of new pimples as well as clearing up existing blemishes; also to sp
eed up skin cell turnover and help the natural exfoliation process of the outer skin layer, which helps clear up pimples and blackheads and reduces the spread of acne.

What are the side effects of Retin-A gel?

The most commonly reported side effects when taking Retin-A gel 0.025% include itching, dryness, redness, burning or peeling at the site of application; these effects are usually mild and happen when you start treatment.

When should Retin-A gel not be used?

You should not use Retin-A gel 0.025% if you:

• are allergic to tretinoin or any ingredients in Retin-A gel
• are pregnant or may become pregnant, as tretinoin may cause birth defects
• have acute eczema, as tretinoin can cause severe irritation on eczematous skin
• have a skin condition such as rosacea or perioral dermatitis
• have a personal or familial history of cutaneous epithelioma
• are using any topical skin peeling medication containing sulphur, resorcinal or salicylic acid
• are exposed to sunlight for prolonged periods; if unavoidable use a sunscreen and protective clothing over treated areas to protect the skin.
• are using other topical medications

Should you avoid exposure to sun?

You should avoid or at least minimize unprotected exposure to sunlight, including sunlamps, while using Retin-A gel 0.025%, as tretinoin can increase your sensitivity to sunlight and may cause burning. Also if you have sunburn, you should wait until your skin has healed before using Retin-A gel. If you cannot avoid exposure to sun because of your occupation, for example, make sure you use a sunscreen and protective clothing over treated areas to protect the skin.

How should Retin-A gel be used?

You should apply your Retin-A gel 0.025% to the affected area of the skin once daily, preferably in the evening before going to bed. Clean the skin with a mild soap or soap-free cleanser, rinse with water then apply a small amount with clean fingers and rub gently into the skin. Do not use large amounts or apply Retin-A gel 0.025% more often than directed, as your skin will not clear up faster; instead you may increase the chance for side effects like skin irritation. Avoid contact with the eyes, eyelids, inside of the nose and mouth, which are easily irritated areas, or other areas where treatment is not intended. Do not apply to severely inflamed skin or to open lesions. You should continue to use your Retin-A gel 0.025% for the full course of treatment as directed by your doctor, until your skin has cleared up and there are no more acne lesions, which may take up to 7 weeks, although you should see signs of improvement after 2 weeks. You may continue to use your Retin-A ge
l 0.025% to maintain your skin after the acne has cleared, depending on your doctor’s recommendations.

How long should you use Retin-A gel?

You should continue to use your Retin-A gel 0.025% for the full course of treatment as directed by your doctor, until your skin has cleared up and there are no more acne lesions, which may take up to 7 weeks, although you should see signs of improvement after 2 weeks. You may continue to use your Retin-A gel 0.025% to maintain your skin after the acne has cleared, depending on your doctor’s recommendations.

Missed dose of Retin-A gel

If you miss a dose of Retin-A gel 0.025% apply it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

How should Retin-A gel be stored?

You should store your Retin-A gel 0.025% below 25°C in a cool dry place.